The game follows investigator and war veteran Edward Pierce, a private detective experiencing an existential crisis. As the setting of 1924 Boston doesn’t provide him with any cases, Pierce stoops to consuming alcohol and pills to satisfy his mind. A glimmer of hope shines when a mysterious case one day lands on his desk. Pierce is asked to solve the death of the Hawkins family, who mysteriously died in a fire. As the only clue is a strange picture painted by the supposedly crazy mother shortly before her death, Edward has to set out to Darkwater Island near Boston, Massachusetts to find out more about the matter. In the process, he discovers the impending revival of the Great Old One Cthulhu.